Dr. habil. László Hegedűs | Department of Organic Chemistry and Technology

Dr. habil. László Hegedűs; PhD

head of department

associate professor

Contact info

Office:

F. I. 2nd floor 204.

Laboratory:

F. I. 2nd floor 204.

Telephone:

+36 1 463 1261

Fax:

+36 1 463 3648

Postal address:

H-1111 Budapest, Műegyetem rkp. 3

E-mail:

Contact person by email

Research group

Heterogeneous Catalytic Reactions Research Group

Professional data

Research interests:

Heterogeneous catalysis: Liquid-phase hydrogenations – Preparation and characterisation of supported precious metal or skeleton catalysts – Chemo- and stereoselective reactions
Synthetic chemistry: Synthesis of pharmaceutical intermediates [e.g. 1-methyl-2-pyrrolidineethanol, tryptamine, melatonin, dacarbazine, 2-(3',4'-diethoxyphenyl)ethylamine, (S)-(+)-2-(N-benzylamino)butan-1-ol, trans-4-aminocyclohexylacetic acid ethyl ester.HCl, 4-(aminomethyl)piperidine.H₂SO₄]

Scientific degrees:

2020: habilitation, BME Faculty of Chemical Technology and Biotechnology (Heterogeneous catalytic hydrogenations in liquid phase)
1997: PhD, BME Faculty of Chemical Engineering (Investigation of the heterogeneous catalytic hydrogenation of pyrrole derivatives)

Studies, degrees:

1993: MSc (chemical engineer), BME Faculty of Chemical Engineering (Department of Organic Chemical Technology; Investigation of the preparation of 1-methyl-2-pyrrolidineethanol)
1991: BSc (chemical engineer), BME Faculty of Chemical Engineering (Department of Organic Chemical Technology; Zeolite catalysis in some organic chemical reactions)
1988-1993: BME Faculty of Chemical Engineering, Branch of organic-synthetic chemistry

Workplaces, positions:

2021-: habil. associate professor, head of department (BME Department of Organic Chemisty and Technology): Selective, heterogeneous catalytic hydrogenations
2020-2021: habil. associate professor, deputy head of department (BME Department of Organic Chemisty and Technology)
2017-2020: associate professor (BME Department of Organic Chemisty and Technology)
2012-2017: senior research fellow (MTA-BME Organic Chemical Technology Research Group)
2007-2011: research fellow (MTA-BME Organic Chemical Technology Research Group)
2006-2007: assistant professor (BME Department of Organic Chemisty and Technology)
2003-2006: HOVIONE-VJA postdoctoral fellow (BME Department of Organic Chemical Technology)
2000-2003: OTKA postdoctoral fellow (BME Department of Organic Chemical Technology)
1998-2000: Magyary Zoltán postdoctoral fellow (BME Department of Chemical Technology)
1993-1997: PhD student (BME Department of Organic Chemical Technology)

Visits:

1999:Porto, Portugal (1 month)

Education

Teaching types:

Leading lab practices (from 1994); Teaching in the English regular education (from 2003); Supervising BSc, MSc or PhD thesis works (from 1998)

Regular teaching:

Lectures: Safety (BSc); Organic chemical technology, correspondence and English courses (BSc); Organic chemical technology II (MSc); Catalysis in organic chemical industry (MSc); Environmentally friendly chemistry and technology (MSc), Organic chemical technology I & II (PhD)
Coordination of practices: Summer professional practice (BSc, MSc) (Richter Gedeon Plc.)
Lab practices: Organic chemical technology (BSc); Chemical technology (BSc); Basic processes of pharmaceutical chemistry (BSc); Environmentally friendly chemistry and technology (MSc); Organic chemical technology II (MSc)

Teaching method/topic development:

Elaboration of the subject matter of Catalysis in organic chemical industry (MSc).
Preparation of educational auxiliary materials for laboratorial practices in Hungarian or in English [Autoclave (BSc), Hydrogenation (MSc)]

Academic administration

Scientific organisation memberships:

National Council of Student Research Societies (OTDT) Professional Committee of Chemistry and Chemical Industry Section - deputy chairman (2023-); Society of Magyary Zoltán Postdoctoral Fellows (1998-2020, manager 2004-2005); Academic Club of Bolyai János Research Fellows (2006-)

Committee membership, Academy of Sciences:

MTA Catalysis Committee (1997-)

Editorial board member:

Periodica Polytechnica Chemical Engineering (2021-)
Symmetry, Section Associate Editor (2021-)
Current Organic Chemistry, Section Editor (2019-)
Letters in Organic Chemistry (2019-)

Referee activity:

International and domestic journals: ACS Applied Materials & Interfaces; ACS Catalysis; ACS Omega; Applied Catalysis A: General; AppliedChem; Applied Sciences; Biomolecules; Carbohydrate Research; Catalysis Communications; Catalysis Letters; Catalysis Science & Technology; Catalysts; ChemCatChem; ChemEngineering; Chemical Communications; Chemical Engineering Journal; Chemical Engineering Research and Design; Chemical Industry and Chemical Engineering Quarterly; ChemistrySelect; ChemSusChem; Chinese Journal of Chemical Engineering; Coordination Chemistry Reviews; Crystals; Current Catalysis; Current Green Chemistry; Current Organic Chemistry; Energies; European Journal of Pharmacology; Fuel; Gels; Hydrogen; IEEE Sensors Journal; Ingeniería y Ciencia; International Journal of Molecular Sciences; Letters in Organic Chemistry; Materials; Micromachines; Molecules; Nanomaterials; New Journal of Chemistry; Organic Process Research & Development; Periodica Polytechnica Chemical Engineering; Phosphorus, Sulfur, and Silicon and the Related Elements; Polymers; Processes; Reaction Kinetics, Mechanisms and Catalysis; RSC Advances; Symmetry; Synthetic Communications; Toxics; Magyar Kémiai Folyóirat
Domestic and international proposals: OTKA, Magyary, National Excellence Program (NEP), New National Excellence Program (NNEP); ANR (France), ERA-OTKA (EU-FP6-Hungary)

Conference organisation:

The 28th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-28, 2024) - Member of the Scientific Committee
XXXIV. OTDK, Section of Chemistry and Chemical Industry (BME VBK, Budapest, 2019) - Chairman of the Organising Committe

Activity in scientific evaluations:

PhD qualification - reviewer and/or member (BME, PE, ELTE)

Leadership

University, Faculty, Department mandates:

BME VBK George Oláh Doctoral School Council (DIT) - member (2022-); BME VBK George Oláh Doctoral School - core member (2022-); BME VBK Faculty Council - member (2020-); National Council of Student Research Societies (OTDT) Professional Committee of Chemistry and Chemical Industry Section - BME VBK representative (2019-2023); BME Talent Support Council - faculty representative (2018-2021); BME VBK Scientific Students’ Association Committee (SSAC) - member (2015-); Department responsible for fire and environmental protection, as well as safety (2015-2021), and precious metals (2001-2021)

Scientific project co-ordination:

Domestic research projects: Project coordinator [OTKA (D-34586, 2000-2003)]

Contract projects :

Domestic contract projects, responsible person (CHEMOCAT Ltd., Euroapi Hungary Ltd.)

Scientific and teaching awards

Scholarship of Hungarian Republic (Ministry of Education, 1992); Balló Rudolf Prize (BME VEK Varga József Foundation, 1996); Magyary Zoltán Postdoctoral Fellowship (FHHER, 1998-2000); OTKA Postdoctoral Fellowship (OTKA, 2000-2003); HOVIONE-VJA Postdoctoral Fellowship (BME VBK Varga József Foundation, 2003-2006); Bolyai János Research Scholarship (MTA, 2006-2009); Wartha Vince Prize (BME VBK Varga József Foundation, 2015); Honorary Associate Professor (BME VBK, 2016); Academy-Patent Award (MTA-SZTNH, 2016); TDK Memorial Plaquette (BME, 2016); Varga József University Prize (MTA, 2018); Fodor Lajos Prize (BME VBK Varga József Foundation, 2019); TDK Teaching Scholarship (Pro Progressio Foundation, 2023).

Publications

Summary of scientific achievements:

2 Book chapters - 102 Articles (IF: 141.0, independent/all citations: 810/1239) - 22 Patents (domestic and international) - 83 Conference lectures or posters

Selected publications:

Book chapters

Tungler, A.; Hegedűs, L.; Fodor, K.; Farkas, G.; Fürcht, Á.; Karancsi, Zs.P.: Reduction of dienes and polyenes in The chemistry of dienes and polyenes, Vol. 2, (Ed. Z. Rappoport), The Chemistry of Functional Groups, Chichester, John Wiley, 2000, pp. 991-1027.

Articles (2014-2024)

Kovács, E.; Faigl, F.; Mucsi, Z.; Nyerges, M.; Hegedűs, L.: Hydrogenolysis of N- and O-protected hydroxyazetidines over palladium: Efficient and selective methods for ring opening and deprotecting reactions, J. Mol. Catal. A: Chem. 2014, 395, 217-224. DOI:10.1016/j.molcata.2014.08.027
Hegedűs, L.; Miskolczi, S.; Bánsághi , Gy.; Székely, E.; Faigl, F.: Synthesis of (S)-(+)-2-(N-benzylamino)butan-1-ol from its Schiff base by catalytic hydrogenation over palladium, Curr. Green Chem. 2015, 2, 312-318. DOI:10.2174/2213346102666150211001310
Varró, G.; Hegedűs, L.; Simon, A.; Balogh, A.; Grün, A.; Leveles, I.; Vértessy, G. B.; Kádas, I.: The first enantioselective total synthesis of (–)-trans-dihydronarciclasine, J. Nat. Prod. 2017, 80, 1909-1917. DOI:10.1021/acs.jnatprod.7b00208
Varró, G.; Mattyasovszky, L.; Grün, A.; Simon, A.; Hegedűs, L.; Kádas, I.: Highly stereoselective synthesis of trans-dihydronarciclasine analogues, Synthesis 2018, 50, 625-643. DOI:10.1055/s-0036-1591514
Hegedűs, L.; Szőke-Molnár, K.; Sajó, I.E.; Srankó, D.F.; Schay Z.: Poisoning and reuse of supported precious metal catalysts in the hydrogenation of N-heterocycles Part I: Ruthenium-catalysed hydrogenation of 1-methylpyrrole, Catal. Lett. 2018, 148, 1939-1950. DOI:10.1007/s10562-018-2406-4
Lévay, K.; Hegedűs, L.: Selective heterogeneous catalytic hydrogenation of nitriles to primary amines, Period. Polytech. Chem. Eng. 2018, 62, 476-488. DOI:10.3311/PPch.12787
Varró, G.; Pálchuber, P.; Pogrányi, B.; Simon, A.; Hegedűs, L.; Kádas, I.: (±)-trans-Dihydronarciclasine and (±)-trans-dihydrolycoricidine analogues modified in their ring A: Evaluation of their anticancer activity and a SAR study, Eur. J. Med. Chem. 2019, 173, 76-89. DOI:10.1016/j.ejmech.2019.04.010
Lévay, K.; Hegedűs, L.: Recent achievements in the hydrogenation of nitriles catalyzed by transitional metals, Curr. Org. Chem. 2019, 23, 1881-1900. DOI:10.2174/1385272823666191007160341
Lévay, K.; Tóth, K.D.; Kárpáti, T.; Hegedűs, L.: Heterogeneous catalytic hydrogenation of 3-phenylpropionitrile over palladium on carbon, ACS Omega 2020, 5, 5487-5497. DOI:10.1021/acsomega.0c00125
Lévay, K.; Kárpáti, T.; Hegedűs, L.: Selective hydrogenation of benzonitrile and its homologues to primary amines over platinum, J. Ind. Eng. Chem. 2021, 101, 687-698. DOI:10.1016/j.jiec.2021.06.002
Lévay, K.; Madarász, J.; Hegedűs, L.: Tuning the chemoselectivity of the Pd-catalysed hydrogenation of pyridinecarbonitriles: An efficient and simple method for preparing pyridyl- or piperidylmethylamines, Catal. Sci. Technol. 2022, 12, 2634-2648. DOI:10.1039/D1CY02295D
Hegedűs, L.; Hell, Z.: Applying heterogeneous catalytic reactions for organic chemical syntheses, Period. Polytech. Chem. Eng. 2023, 67, 520-536. DOI:10.3311/PPch.22745
Madarász, J.; Hegedűs, L.: Novel crystalline salts of 4-piperidyl- and 4-pyridylmethylamines prepared by catalytic hydrogenation of 4-pyridinecarbonitrile: Crystallographic unit cells based on powder XRD patterns by using the DASH program package, Crystals 2024, 14, 938. DOI:10.3390/cryst14110938